The Protein A1M


A1M – a most extraordinary protein

A1M is an endogenous protein with unique properties. It can be described as a “circulating wastebasket” which captures and eliminates toxic substances from the cells’ metabolism. A1M is a therapeutic candidate in diseases where for example hypoxia and inflammation are damaging our cells and tissues.

A1M (alpha-1-microglobulin) is a natural, endogenous protein which has many functions in the body. It may be described as:

  • a protector against free hemoglobin
  • an antioxidant
  • a radical inhibitor
  • a tissue repair agent

A1M has great therapeutic potential

A1M is a candidate for many therapeutic and diagnostic uses. Preclinical studies implies that A1M can prevent and ameliorate some of the damage caused by oxidative stress and inflammation.

Under development: therapies for pre-eclampsia and kidney damage

Two research groups at Lund University, led by Bo Åkerström and Stefan Hansson, focus on two therapeutic areas:

A medication for intravenous treatment is under development. Clinical studies have been performed on animal models.

Kidney damage
Studies are currently being performed to learn more about A1M’s therapeutic effects in different types of kidney damage and disorders.

A1M, alpha-1-microglobulin.