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Kidney damage

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A1M can protect and repair damaged kidney tissue

A1M Pharma’s research over the last five years has shown that the kidneys are amongst the organs which are best protected by the A1M protein. The company has therefore recently devoted resources to developing treatments for kidney damage.

 

In parallel with their studies of preeclampsia, Bo Åkerström and Stefan Hansson’s research groups at Lund University have investigated the effect of oxidative stress in cultured kidney cells and in the kidneys of laboratory animals. Preeclampsia is namely a disease that affects all the organs of the pregnant woman, especially her kidneys (see below).

These experiments have shown unexpectedly positive results when the kidney tissue has been analyzed. In both cases it is clear that A1M appears to have protective and healing properties. Extended studies are now under way to confirm the effects of treatment with A1M and to find out to which renal diseases it can be applied.

Background
In addition to being the body’s waste disposal units, the kidneys are also the control center for the regulation of blood pressure and thus of the body’s salt and fluid balance as well. This means that a degradation in renal function affects virtually every single bodily function.

Serious injury to the kidney’s tissue and functioning can, for example, arise from poisoning and infections as well as in conjunction with major bleeding or lack of oxygen. Examples of more chronic causes for injury and reduced function are diabetes, hypertension and glomerulonephritis, an inflammatory condition in which the kidney’s filtering units – the glomeruli – become damaged. In all these cases, oxidative stress is an important contributory factor to the damage. If the damage is severe, chronic kidney failure can result, requiring dialysis or transplantation.

In connection with pregnancy, the kidneys have to adapt to an altered hormone profile, an increased rate of metabolism and greater volume of blood. As a result, diseases that affect the kidneys, such as diabetes and SLE (Systemic Lupus Erythematosus), may also cause complications in pregnancy. There is also a clear link between kidney disease – even when mild – and preeclampsia.